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Chris Gayle has scored 422 runs off 273 balls against England in T20Is (strike rate 154.58, average 32.46, 30 sixes, out 13 times).
| Runs | 422 |
| Balls | 273 |
| Strike rate | 154.58 |
| Average | 32.46 |
| Fours | - |
| Sixes | 30 |
| Dismissals | 13 |
| 2007 | 66 | 45 | 146.66 | 2 | 33 |
| 2009 | 15 | 8 | 187.50 | 1 | 15 |
| 2010 | 25 | 12 | 208.33 | 1 | 25 |
| 2012 | 60 | 43 | 139.53 | 2 | 30 |
| 2014 | 79 | 65 | 121.53 | 2 | 39.50 |
| 2016 | 104 | 50 | 208 | 1 | 104 |
| 2017 | 40 | 21 | 190.47 | 1 | 40 |
| 2019 | 20 | 16 | 125 | 2 | 10 |
| 2021 | 13 | 13 | 100 | 1 | 13 |
| Wankhede, Mumbai | 100 | 48 | 208.33 | 0 |
| Kennington Oval, London | 81 | 53 | 152.83 | 3 |
| Kensington Oval | 79 | 65 | 121.53 | 2 |
| Riverside Ground, Chester-le-Street | 40 | 21 | 190.47 | 1 |
| Providence Stadium, Providence | 25 | 12 | 208.33 | 1 |
| Daren Sammy Stadium, Gros Islet | 15 | 12 | 125 | 1 |
| Dubai International Cricket Stadium | 13 | 13 | 100 | 1 |
| Warner Park, Basseterre | 5 | 4 | 125 | 1 |
| Eden Gardens, Kolkata | 4 | 2 | 200 | 1 |
| Trent Bridge, Nottingham | 2 | 8 | 25 | 1 |
| James Tredwell | 29 | 31 | 1 / 4 | 106.89 | 1 |
| David Willey | 27 | 53 | 3 / 6 | 196.29 | 1 |
| Ryan Sidebottom | 23 | 43 | 7 / 1 | 186.95 | 1 |
| Jade Dernbach | 22 | 27 | 3 / 1 | 122.72 | 0 |
| James Anderson | 16 | 24 | 5 / 0 | 150 | 1 |
| Chris Jordan | 16 | 19 | 2 / 1 | 118.75 | 1 |
| Stuart Broad | 15 | 20 | 3 / 0 | 133.33 | 0 |
| Tim Bresnan | 15 | 17 | 3 / 0 | 113.33 | 0 |
| Moeen Ali | 14 | 33 | 1 / 4 | 235.71 | 0 |
| Graeme Swann | 13 | 18 | 0 / 2 | 138.46 | 2 |
| Steven Finn | 11 | 7 | 1 / 0 | 63.63 | 1 |
| Ben Stokes | 10 | 24 | 1 / 3 | 240 | 0 |
| Ravi Bopara | 9 | 11 | 1 / 0 | 122.22 | 1 |
| Reece Topley | 8 | 15 | 2 / 1 | 187.50 | 0 |
| Dimitri Mascarenhas | 7 | 13 | 1 / 1 | 185.71 | 0 |
| Tom Curran | 7 | 12 | 1 / 1 | 171.42 | 0 |
| Chris Woakes | 7 | 9 | 2 / 0 | 128.57 | 0 |
| Adil Rashid | 6 | 15 | 0 / 2 | 250 | 0 |
| Tymal Mills | 6 | 4 | 1 / 0 | 66.66 | 1 |
| Samit Patel | 4 | 18 | 0 / 3 | 450 | 0 |
| Paul Collingwood | 3 | 3 | 0 / 0 | 100 | 1 |
| Joe Root | 2 | 4 | 1 / 0 | 200 | 1 |
| Michael Yardy | 2 | 2 | 0 / 0 | 100 | 0 |
| Liam Plunkett | 1 | 0 | 0 / 0 | 0 | 1 |
Chris Gayle has scored 422 runs off 273 balls against England in T20Is (strike rate 154.58, average 32.46, 30 sixes, out 13 times).